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INTERNATIONAL JOURNAL OF CREATIVE RESEARCH THOUGHTS - IJCRT (IJCRT.ORG)
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Authors
Yash Kumar Sonker
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Keywords: Gut microbiome, type 1 diabetes, hyperammonaemia, metagenomics, bioinformatics, taxonomic profiling, functional annotation, comparative analysis.
Abstract
The microbiome in our gut is very important for many bodily functions and has been linked to the development of several diseases. Metabolic disorders like type 1 diabetes and hyperammonaemia have been linked to dysbiosis, which is an imbalance in the gut microbial population. The point of this study was to use bioinformatics to compare the gut microbiome makeup and functional profiles of people with type 1 diabetes and hyperammonaemia. Bioinformatics tools were used to check the metagenomic sequences for quality, identify taxonomic groups, and label their functions. Comparative studies were done to find out which taxa and functional pathways were more common or less common in the disease groups compared to the healthy controls. Taxonomic profiling showed that people with type 1 diabetes and hyperammonaemia had different microbial signatures than healthy controls. Lack of butyrate-producing bacteria like Faecal bacterium and Roseburia was seen in the type 1 diabetes group, while Proteobacteria and other pro-inflammatory taxa were more common. The hyperammonaemia group, on the other hand, had more urease-producing bacteria, such as Streptococcus and Staphylococcus. In both disease groups, functional annotation showed changes in metabolic pathways linked to the breakdown of carbohydrates and amino acids. This study shows the utility of bioinformatics approaches in elucidating the distinct gut microbiome signatures associated with type 1 diabetes and hyperammonaemia. The observed differences in microbial composition and functional profiles provide insights into the possible roles of the gut microbiome in the pathogenesis of these diseases. These results lay the groundwork for future research investigating the gut microbiome as a therapeutic target or diagnostic biomarker for metabolic disorders.
IJCRT's Publication Details
Unique Identification Number - IJCRT24A5584
Paper ID - 262495
Author type - Indian Author
Page Number(s) - n936-n944
Pubished in - Volume 12 | Issue 5 | May 2024
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No Of Downloads - 22
Author Country - India, 284001, JHANSI, JHANSI, 284001, Life Sciences All
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Yash Kumar Sonker, "Metagenomics Analysis Of Human Gut Microbiome", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.12, Issue 5, pp.n936-n944, May 2024, Available at :http://www.ijcrt.org/papers/IJCRT24A5584.pdf
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