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  Paper Title        

A PROSPECTIVE OBSERVATIONAL COMPARATIVE STUDY ON THE EFFICACY OF ALTEPLASE VERSUS TENECTEPLASE IN ACUTE ISCHEMIC STROKE AND TO ASSESS THE CHANGES IN QUALITY OF LIFE IN THESE PATIENTS AFTER THROMBOLYTIC THERAPY- A PILOT STUDY.

  Authors

AJAY ANAND.S ,GILAS.G,ANANTHAKRISHNAN.S,FATHIMA SHAJAHAN,SOUMYA.R. V,MALINI GOPINATH,JULIA.J.J,PRASOBH.G.R

  Keywords

Acute ischemic stroke, Tenecteplase, Alteplase, NIHSS, MRS, SS-QOL, HADS.

  Abstract


ABSTRACT: Background: Acute ischemic stroke describes a Stroke is often referred to as a brain attack or "cerebrovascular Accident (CVA). A clot blocks a blood vessel that delivers oxygen and nutrients to the brain or bursts (or ruptures), resulting in a stroke. When this happens, brain cells in that location cannot get the blood (or oxygen) they need and perish. Alteplase and Tenecteplase are thrombolytic drugs used for ischemic stroke. Alteplase converts fibrinogen to the proteolytic enzyme plasmin, which lysis fibrin as well as fibrinogen Tenecteplase converts plasminogen to plasmin is increased relative to its conversion in the absence of fibrin. Methods: The study was carried out on 20 patients with AIS. The study was conducted by categorizing them into two groups, 10 patients were treated with Alteplase, and 10 patients were treated with Tenecteplase. The efficacy of Alteplase and Tenecteplase is assessed by using NIHSS and MRS. Health-related QOL of Alteplase and Tenecteplase was assessed using an SS-QOL questionnaire in patients with AIS. Anxiety and depression are assessed by HADS. The cost of both drugs is compared. Result: By using NIHSS and MRS it is assessed that Tenecteplase is more effective than Alteplase. The QOL in Tenecteplase patient show significant change as compared to Alteplase.

  IJCRT's Publication Details

  Unique Identification Number - IJCRT2305385

  Paper ID - 236567

  Author type - Indian Author

  Page Number(s) - c909-c947

  Pubished in - Volume 11 | Issue 5 | May 2023

  DOI (Digital Object Identifier) -   

  No Of Downloads - 76

  Author Country - India, 629151, KANYAKUMARI, KANYAKUMARI, 629151, Pharmacy All

  Publisher Name - IJPUBLICATION | www.ijcrt.org | ISSN : 2320-2882

  E-ISSN Number - 2320-2882

  Published Paper PDF : - http://www.ijcrt.org/papers/IJCRT2305385

  Published Paper URL: : - http://ijcrt.org/viewfull.php?&p_id=IJCRT2305385

  Published Paper PDF Downlaod: - download.php?file=IJCRT2305385

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AJAY ANAND.S ,GILAS.G,ANANTHAKRISHNAN.S,FATHIMA SHAJAHAN,SOUMYA.R. V,MALINI GOPINATH,JULIA.J.J,PRASOBH.G.R,   "A PROSPECTIVE OBSERVATIONAL COMPARATIVE STUDY ON THE EFFICACY OF ALTEPLASE VERSUS TENECTEPLASE IN ACUTE ISCHEMIC STROKE AND TO ASSESS THE CHANGES IN QUALITY OF LIFE IN THESE PATIENTS AFTER THROMBOLYTIC THERAPY- A PILOT STUDY.", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.11, Issue 5, pp.c909-c947, May 2023, Available at :http://www.ijcrt.org/papers/IJCRT2305385.pdf

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