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  Authors

JANSARI JAY R,GEVARIYA VISHWA C,JANSARI TRUPTI R,CHAUHAN AMIT P

  Keywords

Sickle cell trait, Thallasemia, Antenatal, Prevalence

  Abstract


Background: Hemoglobinopathies are a group of genetic disorders of hemoglobin. They affect 4.5% of the world population.6 Approximately 250 million people constituting 4.5% of the world population carry a potentially pathological hemoglobinopathy gene. The sickle cell anemia and thalassemia are the most severe forms of genetic disorders and hence are of great importance to be dealt with from public health point of view in India. The hemoglobinopathies encompasses all genetic diseases of hemoglobin. Early antenatal detection followed by prenatal testing is the key to prevention of the birth of homozygous children. Antenatal screening is the important step to identify women having the risk of producing a child affected with hemoglobinopathy. Aims and Objectives: The aim of the present study was to estimate the prevalence of sickle cell trait(SCT) and beta thalassemia trait (BTT) amongst the women attending Antenatal Clinics (ANC). Materials and methods: This cross sectional, retrospective study included all pregnant women attending ANC clinics in a tertiary care hospital from 15 January 2021 to 15 august 2021. After obtaining the ethical approval, the demographic data and HPLC(High Performance Liquid Chromatography) results were recorded. The HPLC was performed on BioRad D10 Analyser. Collected data were compiled in Microsoft office Excel sheet and analysed using Epi-info statistical software. Descriptive and analytical statistical methods were used for the preparation of results. Data is presented in tabulated as well as graphical format. Results: Total 6029 patients were screened. Out of this 218 cases were of SCT, 13 cases of SCT+BTT. 160(69%) cases were from age-group of 20-25 years. Total prevalence of SCT was 3.61% and that of cases with SCT+BTT was 0.21%. Conclusion: We found that sickle cell trait is more prevalent than beta thallasemia trait. Early antenatal screening followed by prenatal testing is the most feasible approach for the prevention of the birth of homozygous childen. Public health education programs plays the vital role to raise the awareness.

  IJCRT's Publication Details

  Unique Identification Number - IJCRT2210331

  Paper ID - 226708

  Author type - Indian Author

  Page Number(s) - c790-c798

  Pubished in - Volume 10 | Issue 10 | October 2022

  DOI (Digital Object Identifier) -   

  No Of Downloads - 119

  Author Country - India, 390019, VADODARA, VADODARA, 390019, Humanities All

  Publisher Name - IJPUBLICATION | www.ijcrt.org | ISSN : 2320-2882

  E-ISSN Number - 2320-2882

  Published Paper PDF : - http://www.ijcrt.org/papers/IJCRT2210331

  Published Paper URL: : - http://ijcrt.org/viewfull.php?&p_id=IJCRT2210331

  Published Paper PDF Downlaod: - download.php?file=IJCRT2210331

  Cite this article

JANSARI JAY R,GEVARIYA VISHWA C,JANSARI TRUPTI R,CHAUHAN AMIT P,   "�PREVALENCE OF SICKLE CELL TRAIT AND BETA THALASSEMIA TRAIT IN PREGNANT WOMEN: A STUDY AT TERTIARY CARE HOSPITAL�", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.10, Issue 10, pp.c790-c798, October 2022, Available at :http://www.ijcrt.org/papers/IJCRT2210331.pdf

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