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Introduction: The treatment of mental disorder depends on the cause or diagnosis. The first line treatment for many disorders is antipsychotic drugs. There are growing evidence that behavior therapy, family therapy, group therapy can be effective in managing symptoms. When other treatments for psychosis are ineffective, one such treatment which is beneficial is electroconvulsive therapy (ECT) is utilized to relieve symptoms of psychosis. The aim of the study was to assess the effectiveness of structured teaching program on knowledge of nursing students regarding ECT in College of Nursing, CMC & Hospital, Ludhiana, Punjab. Methods: Quasi experimental two group pretest and posttest design was considered to be appropriate, Purposive sampling technique was used by inclusion/ exclusion criteria to select the subjects for the sample. The total sample size for study was 60 nursing students this includes B.Sc (N) interns and GNM 3rd year. The data collection procedure was carried out in the month of February with the help of a systematically prepared structured questionnaire. Pretest was taken first from both control and experimental group. The time given for pretest was and posttest was 20-30 minutes. Posttest of control group was taken on 3rd day after pretest and on the next day structured teaching was given to the experimental group with the help of lesson plan and AV aids. The time spent in the structured teaching was 30-40 minutes. The control group was not exposed to structured teaching. The posttest of the experimental group was conducted on 4th day after structured teaching. Results: According to age in control group majority of nursing students were in the age group of 19-21years (53.3%) followed by 22-24years (43.3%) and in age group > 24 years (3.3%) respectively. In the experimental group majority of nursing students were in the age group of 19-21years (63.3%) followed by 22-24years (33.3%) and in age group > 24 years (3.3%) respectively. According to type of course in both the control and experimental groups B.Sc (N) interns (50%) and GNM 3rd year (50%) nursing students were there respectively. According to religion majority of nursing students in control and experimental group were Christian (40% and 66.6%) followed by hindu and sikh (30% and 16.6%) respectively. According to source of information in control and group, majority of nursing students were having information from TV/ Internet, (63.3%) followed by from Parents/ Relatives/ Friends (26.6%) and Journal/ Magazine/ Newspaper (10%) respectively. In the experimental group majority of nursing students were having information from TV/ Internet, (60%) followed by from Parents/ Relatives/ Friends (23.3%) and Journal/ Magazine/ Newspaper (16.6%) respectively. The pretest and posttest mean knowledge compared and was statically highly significant at p<0.001 level among nursing students in experimental group.