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  Authors

Sami Ullah Mujoo,Asif Iqbal,Umera Ikram,Rukhsana Najeeb

  Keywords

Dexmedetomidine, haemodynamic pressor response, laparoscopic hernia repair.

  Abstract


Background and Aim: Dexmedetomidine is a ?2 agonist drugs which acts at both supraspinal and spinal level and modulate the transmission of nociceptive signals in the central nervous system. This drug has become an ideal adjuvant during general anesthesia, especially when stress is expected. The aim of this study was to see the efficiency of low dose of dexmedetomidine infusion on haemodynamic response during laryngoscopy, endotracheal intubation, creation of pneumoperitoneum and extubation in patients undergoing laparoscopic hernia repair. Methods: Sixty patients of American Society of Anesthesiologists (ASA) physical status I and II undergoing laparoscopic hernia repair were randomly allocated into two groups of 30 patients each. Group X received 50 ml NS and Group Y received Dexmedetomidine 0.6mcg/kg/hr (0.5 ml in normal saline 50ml/hr). All the patients were observed for vitals like HR, MAP, oxygen saturation at regular intervals including before starting the infusion, 10 minutes after starting the infusion, after induction, after intubation, after creation of pneumoperitoneum and after extubation.Patients were also observed for post-operative sedation and analgesia requirements. The results were statistically done using spss (statistical package for social sciences) soft ware version 15.0, chi-square test was used for qualitative (sex) HR, SBP, DBP. P-value< 0.05 was considered statistically significant. Results: In Group NS, after starting the infusion there was no significant change in HR and MAP but these increased significantly above the baseline values after intubation and extubation (p<0.01) and significantly after pneumoperitoneum (p<0.05). While as in Dexmedetomidine groups, after starting the infusion, HR decreased significantly below the baseline value and MAP also decreased highly significantly among the patients who receive dexmedetomidine infusion. Pneumoperitoneum did not produce significant effect in dexmedetomidine group. Conclusion: Infusion dose of 0.6mcg/kg/hr without any bolus dose serves very good adjuvant to control haemodynamic pressor response to intubation, pneumoperitoneum and extubation in patients undergoing laparoscopic hernia repair.

  IJCRT's Publication Details

  Unique Identification Number - IJCRT2011243

  Paper ID - 200846

  Author type - N

  Page Number(s) - 1967-1976

  Pubished in - Volume 8 | Issue 11 | November 2020

  DOI (Digital Object Identifier) -   

  No Of Downloads - 1221

  Author Country - -, -, -, -, -, Science & Technology

  Publisher Name - IJPUBLICATION | www.ijcrt.org | ISSN : 2320-2882

  E-ISSN Number - 2320-2882

  Published Paper PDF : - http://www.ijcrt.org/papers/IJCRT2011243

  Published Paper URL: : - http://ijcrt.org/viewfull.php?&p_id=IJCRT2011243

  Published Paper PDF Downlaod: - download.php?file=IJCRT2011243

  Cite this article

Sami Ullah Mujoo,Asif Iqbal,Umera Ikram,Rukhsana Najeeb,   "EFFICACY OF DEXMEDETOMIDINE ON PRESSOR RESPONSE IN PATIENTS UNDERGOING ELECTIVE LAPAROSCOPIC HERNIA REPAIR. A PROSPECTIVE RANDOMISED CONTROLLED STUDY.", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.8, Issue 11, pp.1967-1976, November 2020, Available at :http://www.ijcrt.org/papers/IJCRT2011243.pdf

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