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INTERNATIONAL JOURNAL OF CREATIVE RESEARCH THOUGHTS - IJCRT (IJCRT.ORG)
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ISSN Approved Journal No: 2320-2882 | Impact factor: 7.97 | ESTD Year: 2013
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Paper Title
FORMULATION ASPECTS OF EZETIMIBE LYOPHILIZED DRY EMULSION TABLETS
Authors
Kartik Sharad Sonej, Miss. Dipika Hiraman Gosavi, Vaibhav Machhindra Sawant, Dhiraj Anil Pawar, Prasad Shavan Surse
Keywords
Ezetimibe, lyophilized dry emulsion tablet, and hyperlipidemia, freeze drying, Labrafac
Abstract
Ezetimibe is the first lipid-lowering drug that inhibits the intestinal absorption of dietary and biliary cholesterol without affecting the absorption of fat-soluble nutrients. After oral administration, ezetimibe is rapidly absorbed and extensively metabolized (>80%) to the pharmacologically active ezetimibe-glucuronide. Total ezetimibe (the sum of 'parent' ezetimibe plus ezetimibe-glucuronide) concentrations reach a maximum 1-2 hours after administration, followed by enterohepatic recycling and gradual elimination. The terminal half-life of ezetimibe and ezetimibe-glucuronide is approximately 22 hours. Consistent with the elimination half-life of ezetimibe, approximately 2-fold accumulation is observed after once-daily dosing. The recommended dose of ezetimibe 10 mg/day can be given in the morning or evening without regard to food.
IJCRT's Publication Details
Unique Identification Number - IJCRT2301393
Paper ID - 230112
Page Number(s) - d98-d102
Pubished in - Volume 11 | Issue 1 | January 2023
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Publisher Name - IJCRT | www.ijcrt.org | ISSN : 2320-2882
E-ISSN Number - 2320-2882
Cite this article
Kartik Sharad Sonej, Miss. Dipika Hiraman Gosavi, Vaibhav Machhindra Sawant, Dhiraj Anil Pawar, Prasad Shavan Surse, "FORMULATION ASPECTS OF EZETIMIBE LYOPHILIZED DRY EMULSION TABLETS", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.11, Issue 1, pp.d98-d102, January 2023, Available at :http://www.ijcrt.org/papers/IJCRT2301393.pdf
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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