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  Published Paper Details:

  Paper Title

THE EFFECT OF EBOLA VIRUS ON HUMAN IMMUNE SYSTEM

  Authors

  Udit Gupta,  Poorvi Kamble ,  Sruthi Menon,  Christopher Antony K,  Sahil Vithalani

  Keywords

Ebola virus, Filovirus Hemorrhagic fever, intrinsic proteins, monoclonal antibodies.

  Abstract


Ebola virus disease, formerly known as Ebola hemorrhagic fever, is a rare but severe disease which is often fatal in humans if untreated. Ebola was first identified as a possible new �strain� of the Marburg virus in 1976 which caused two simultaneous outbreaks, one in Nzara (South Sudan) and the other in Yambuku (DRC). The International Committee on Taxonomy of Viruses (ICTV) identified Ebola virus as species, Zaire Ebola Virus which belongs to the family Filoviridae. Ebola virus contains a Negative-sense, single stranded RNA and it encodes for seven different proteins including one extrinsic protein, glycoprotein and six different intrinsic proteins, VP24, VP35, VP24, VP40, VP30, Nucleoproteins, L-polymerase. EBOV infection obstructs DC maturation without inducing cytokine expression, leading to impaired T-cell proliferation. Whereas macrophages produce selective proinflammatory cytokines and certain tissue factor which attract additional target cells that in turn induces vasodilation and causes vascular permeability and disseminated intravascular coagulation. There are a few treatment methods which have been proven effective against the Zaire EBOV and some monoclonal antibody-based drugs have also been used. Only one FDA approved vaccine, rVSV ZBOV is available.

  IJCRT's Publication Details

  Unique Identification Number - IJCRT2007632

  Paper ID - 197402

  Page Number(s) - 5648-5654

  Pubished in - Volume 8 | Issue 7 | July 2020

  DOI (Digital Object Identifier) -    http://doi.one/10.1729/Journal.24192

  Publisher Name - IJCRT | www.ijcrt.org | ISSN : 2320-2882

  E-ISSN Number - 2320-2882

  Cite this article

  Udit Gupta,  Poorvi Kamble ,  Sruthi Menon,  Christopher Antony K,  Sahil Vithalani,   "THE EFFECT OF EBOLA VIRUS ON HUMAN IMMUNE SYSTEM", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.8, Issue 7, pp.5648-5654, July 2020, Available at :http://www.ijcrt.org/papers/IJCRT2007632.pdf

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ISSN: 2320-2882
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ISSN and 7.97 Impact Factor Details


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ISSN: 2320-2882
Impact Factor: 7.97 and ISSN APPROVED
Journal Starting Year (ESTD) : 2013
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